how to use tremfya how to use tremfya

how to use tremfya®

what is tremfya

What is Tremfya®?2

Tremfya® comes as an injectable pre-filled pen for administration by subcutaneous injection (under the skin).2

Each injectable of Tremfya® contains 100 mg of guselkumab in a 1mL solution.

How to administer Tremfya®

Please see the video for how to administer Tremfya®.

how often to take Tremfya

How often to take Tremfya®2

Tremfya® is supplied as an injectable pre-filled pen for administration by a subcutaneous injection, meaning an injection under the skin.2

The recommended dose of Tremfya® is 100mg. Your injectable pre-filled pen comes with one 100mg dose.

At the beginning of your treatment, you will receive one dose at week 0 and 4 (this is the induction phase) followed by one dose every 8 weeks (maintenance).

The recommended dose of Tremfya® is 100mg. Your injectable pre-filled pen comes with one 100mg dose.

At the beginning of your treatment, you will receive one dose at week 0 and 4 (this is the induction phase) followed by one dose every 8 weeks (maintenance). A dose of 100mg every 4 weeks may be considered by your clinician.

The dosing schedule for a patient receiving their first Tremfya® dose on 1st January.




























Do you have questions about your Tremfya® dose?

Speak to your doctor or nurse if:

  • You are unsure when your next dose of Tremfya® is due
  • You use more Tremfya® than you should have, such as receiving a larger dose or using it sooner than planned
  • You forget to administer a dose
  • You would like to stop using Tremfya®. Your symptoms may return if you stop treatment

The Tremfya® treatment journey: Year one

If you’re starting Tremfya® and wondering what will happen with your treatment in the first year the timeline below has the information

week 0: the starter dose

You will receive your first injection by a doctor or nurse at your hospital or clinic, or by a nurse who visits you at home. The nurse visiting your home may also train you to self-inject, if it is decided that this is an appropriate option for you.

week 4: the second starter dose

From this point on you will receive one dose of Tremfya every 8 weeks.2

week 4: the second starter dose

week 12: the first maintenance dose

This is your first maintenance dose and from now on, all doses will be every eight weeks.2

first maintenance dose

Noticing any changes?

It may be helpful to use a journal or take pictures to document changes in your condition. If you experience any negative symptoms on Tremfya®, contact your healthcare professional immediately.


week 16: visible results

By this time you can expect to see a visible improvement in your psoriasis.

If your psoriasis hasn't responded to Tremfya by now, your healthcare professional may decide to stop or change your treatment.

week 20: the second maintenance dose

Make sure you’re staying in touch with your doctor or nurse in case you have any questions.


week 28: the third maintenance dose

You’re past the halfway mark of your first year on Tremfya®!


week 36: the fourth maintenance dose

Keep tracking your progress to see how far you’ve come.


week 44: the fifth maintenance dose

You’ve almost completed your first year on Tremfya®!


week 52: one year of tremfya®

Your first year on Tremfya® is complete! You will continue to have check-ups with your healthcare professional, to make sure your psoriasis is still responding well to treatment and you’re happy with your medication. If you have concerns or questions at any point, contact your healthcare professional.

after year one

You have completed one year of treatment and can expect the improvements you have seen in your psoriasis to continue. If you stop treatment, your symptoms may come back. You should not stop using Tremfya without speaking to your doctor first.2

Please speak to your doctor or nurse if you have any questions or concerns.

What you need to know before you use Tremfya®2

do not use tremfya

Do not use Tremfya® - +

  • If you are allergic to guselkumab or any of the other ingredients of this medicine. If you think you may be allergic, ask your doctor for advice before using Tremfya®
  • If you have an active infection, including active tuberculosis
  • If the medicine has passed its expiry date which is stated on the pre-filled pen label and on the outer carton after "EXP". The expiry date refers to the last day of that month
  • If you notice that the medicine is cloudy or discoloured, or contains large particles.
warnings and precautions

Warnings and precautions - +

Talk to your doctor, pharmacist or nurse before using Tremfya® if:

  • You are being treated for an infection
  • You have an infection that does not go away or that keeps coming back
  • You have tuberculosis or have been in close contact with someone with tuberculosis
  • You think you have an infection or have symptoms of an infection (see below under ‘look out for infections and allergic reactions’)
  • You have recently had a vaccination or if you are due to have a vaccination during treatment with Tremfya®
look out for infections and allergic reactions

Look out for infections and allergic reactions - +

Tremfya® may lower your ability to fight infections and may therefore increase your risk of infections and allergic reactions. Tell your doctor or seek medical help immediately if you notice any signs of an infection or an allergic reaction while you are taking Tremfya®.

Signs of infection can be:

  • Fever or flu like symptoms
  • Muscle aches
  • Cough
  • Shortness of breath
  • Blood in your phlegm (mucus)
  • Weight loss
  • Diarrhoea or stomach pain
  • Warm, red, or painful skin or sores on your body which are different from your psoriasis
  • Burning when you urinate, or urinating more often than usual

Signs of allergic reaction can be:

  • Difficulty breathing or swallowing
  • Swelling of the face, lips, tongue or throat
  • Severe itching of the skin, with a red rash or raised bump
children and adolescents

Children and adolescents - +

Tremfya® is not recommended for children and adolescents under 18 years of age because it has not been studied in this age group.

other medicines and tremfya

Other medicines and Tremfya® - +

Tell your doctor or pharmacist:

  • If you are using, have recently used or might use any other medicines
  • If you recently had or are due to have a vaccination. You should not be given certain types of vaccines (live vaccines) while using Tremfya®
pregnancy and breast feeding

Pregnancy and breast-feeding - +

  • Tremfya® should not be used in pregnancy as the effects of this medicine in pregnant women are not known. If you are a woman of childbearing potential, you are advised to avoid becoming pregnant and must use adequate contraception while using Tremfya® and for at least 12 weeks after the last Tremfya® dose. Talk to your doctor if you are pregnant, think you may be pregnant or are planning to have a baby
  • Talk to your doctor if you are breast-feeding or are planning to breast-feed. You and your doctor should decide if you will breast-feed or use Tremfya®
driving and using machines

Driving and using machines - +

Tremfya® is unlikely to influence your ability to drive and use machines.

how to administer tremfya

How to administer Tremfya® - +

Please see the Patient Information Leaflet for instructions on how to administer Tremfya®


Janssen Immunology Patient Support Programme is a free service available to all patients that have been prescribed Tremfya. It is a Training & Education Service to empower you to self-inject your medication in the comfort of familiar surroundings.
You and your healthcare professional will discuss the type of homecare service that is most appropriate for you.

home training visits

Home training visits

After you have collected your medication from your local pharmacy, a qualified nurse will visit you in your home, or location of your choice, to train you how to self-administer. You can then move onto receiving regular reminder texts or calls to help you remember to take your medicine.

home delivery

Sharps delivery/collection

Once you have been trained by a fully qualified nurse and are comfortable with self injecting, you can avail of the sharps bin delivery and collection service.

Possible side effects2

Reporting side effects

Adverse events should be reported. This medicinal product is subject to additional monitoring and it is therefore important to report any suspected adverse events related to this medicinal product. Healthcare professionals are asked to report any suspected adverse events via HPRA Pharmacovigilance Website:
Adverse events should also be reported to Janssen Sciences Ireland UC on 1800 709 122 or at

What are the possible side effects?

Like all medications, Tremfya® can cause side effects, although not everyone will get them.

The side effects listed below have all been reported to be mild to moderate in clinical studies. If you experience any of these side effects or they become severe, speak to your healthcare professional as soon as possible:

Very common side effects:2

(may affect more than 1 in 10 people)

  • Upper respiratory infections

Common side effects:2

(may affect up to 1 in 10 people)

  • Headache
  • Joint pain (arthralgia)
  • Diarrhoea
  • Redness, irritation or at the injection site
  • Increased level of liver enzymes in the blood

Uncommon side effects:2

(may affect up to 1 in 100 people)

  • Allergic reaction
  • Skin rash
  • Decreased number of a type of white blood cell called neutrophils
  • Herpes simplex infection
  • Fungal infections of the skin, for instance between the toes (e.g., athelete's foot)
  • Stomach flu
  • Hives